The tumour antigen PRAME is a subunit of a Cul2 ubiquitin ligase and associates with active NFY promoters

The human tumour antigen PRAME (preferentially expressed antigen of melanoma) is frequently overexpressed in tumours. High PRAME levels correlate with poor clinical outcome of several cancers, but the mechanisms by which PRAME could be involved in tumourigenesis remain largely elusive. We applied pr...

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Detalhes bibliográficos
Main Authors: Costessi, Adalberto, Mahrour, Nawel, Tijchon, Esther, Stunnenberg, Rieka, Stoel, Marieke A, Jansen, Pascal W, Sela, Dotan, Martin-Brown, Skylar, Washburn, Michael P, Florens, Laurence, Conaway, Joan W, Conaway, Ronald C, Stunnenberg, Hendrik G
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2011
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3173790/
https://ncbi.nlm.nih.gov/pubmed/21822215
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/emboj.2011.262
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