MUC1c Regulates Cell Survival in Pancreatic Cancer by Preventing Lysosomal Permeabilization

BACKGROUND: MUC1 is a type I transmembrane glycoprotein aberrantly overexpressed in various cancer cells including pancreatic cancer. The cytosolic end of MUC1 (MUC1-c) is extensively involved in a number of signaling pathways. MUC1-c is reported to inhibit apoptosis in a number of cancer cells, but...

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Bibliografiske detaljer
Main Authors: Banerjee, Sulagna, Mujumdar, Nameeta, Dudeja, Vikas, Mackenzie, Tiffany, Krosch, Tara K., Sangwan, Veena, Vickers, Selwyn M., Saluja, Ashok K.
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2012
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3418232/
https://ncbi.nlm.nih.gov/pubmed/22912777
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0043020
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