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MUC1c Regulates Cell Survival in Pancreatic Cancer by Preventing Lysosomal Permeabilization
BACKGROUND: MUC1 is a type I transmembrane glycoprotein aberrantly overexpressed in various cancer cells including pancreatic cancer. The cytosolic end of MUC1 (MUC1-c) is extensively involved in a number of signaling pathways. MUC1-c is reported to inhibit apoptosis in a number of cancer cells, but...
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| Hauptverfasser: | , , , , , , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
Public Library of Science
2012
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3418232/ https://ncbi.nlm.nih.gov/pubmed/22912777 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0043020 |
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