Topical application of disodium isostearyl 2-O-L-ascorbyl phosphate, an amphiphilic ascorbic acid derivative, reduces neuropathic hyperalgesia in rats

BACKGROUND AND PURPOSE: Ca(v)3.2 T-type calcium channels, targeted by H(2)S, are involved in neuropathic hyperalgesia in rats and ascorbic acid inhibits Ca(v)3.2 channels. Therefore, we evaluated the effects of intraplantar (i.pl.) administration of ascorbic acid or topical application of disodium i...

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Main Authors: Okubo, Kazumasa, Nakanishi, Hiroki, Matsunami, Maho, Shibayama, Hiroharu, Kawabata, Atsufumi
Formato: Artigo
Idioma:Inglês
Publicado em: Blackwell Publishing Ltd 2012
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Research Papers
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3417429/
https://ncbi.nlm.nih.gov/pubmed/22229645
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1476-5381.2012.01835.x
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