Topical application of disodium isostearyl 2-O-L-ascorbyl phosphate, an amphiphilic ascorbic acid derivative, reduces neuropathic hyperalgesia in rats

BACKGROUND AND PURPOSE: Ca(v)3.2 T-type calcium channels, targeted by H(2)S, are involved in neuropathic hyperalgesia in rats and ascorbic acid inhibits Ca(v)3.2 channels. Therefore, we evaluated the effects of intraplantar (i.pl.) administration of ascorbic acid or topical application of disodium i...

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Hlavní autoři: Okubo, Kazumasa, Nakanishi, Hiroki, Matsunami, Maho, Shibayama, Hiroharu, Kawabata, Atsufumi
Médium: Artigo
Jazyk:Inglês
Vydáno: Blackwell Publishing Ltd 2012
Témata:
Research Papers
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3417429/
https://ncbi.nlm.nih.gov/pubmed/22229645
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1476-5381.2012.01835.x
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