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Partial Escape of HIV-1 from Cytotoxic T Lymphocytes during Chronic Infection

Viral mutational escape from CD8(+) cytotoxic T lymphocytes (CTLs) is typically considered to be a dichotomous process and uncommon during chronic HIV-1 infection. Ex vivo passaging of HIV-1 from persons with chronic infection, however, revealed the evolution of many fixed substitutions within and a...

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Autori principali: Lewis, Martha J., Dagarag, Mirabelle, Khan, Basim, Ali, Ayub, Yang, Otto O.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Microbiology 2012
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3416319/
https://ncbi.nlm.nih.gov/pubmed/22553321
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.06724-11
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