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Evidence for a Genetic and Physical Interaction between Nonstructural Proteins NS1 and NS4B That Modulates Replication of West Nile Virus

Flavivirus NS1 is a nonstructural glycoprotein that is expressed on the cell surface and secreted into the extracellular space. Despite its transit through the secretory pathway, NS1 is an essential gene linked to early viral RNA replication. How this occurs has remained a mystery given the disparat...

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Détails bibliographiques
Auteurs principaux: Youn, Soonjeon, Li, Tuo, McCune, Broc T., Edeling, Melissa A., Fremont, Daved H., Cristea, Ileana M., Diamond, Michael S.
Format: Artigo
Langue:Inglês
Publié: American Society for Microbiology 2012
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3416313/
https://ncbi.nlm.nih.gov/pubmed/22553322
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.00157-12
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