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c-Src Links a RANK/αvβ3 Integrin Complex to the Osteoclast Cytoskeleton
RANK ligand (RANKL), by mechanisms unknown, directly activates osteoclasts to resorb bone. Because c-Src is key to organizing the cell's cytoskeleton, we asked if the tyrosine kinase also mediates RANKL-stimulated osteoclast activity. RANKL induces c-Src to associate with RANK(369–373) in an αv...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
American Society for Microbiology
2012
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3416198/ https://ncbi.nlm.nih.gov/pubmed/22615494 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.00077-12 |
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