Lineage-Specific Differences between Human and Simian Immunodeficiency Virus Regulation of gp120 Trimer Association and CD4 Binding

Metastable conformations of the gp120 and gp41 envelope glycoproteins of human immunodeficiency virus type 1 (HIV-1) and simian immunodeficiency virus (SIV) must be maintained in the unliganded state of the envelope glycoprotein trimer. Binding of gp120 to the primary receptor, CD4, triggers the tra...

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Détails bibliographiques
Auteurs principaux: Finzi, Andrés, Pacheco, Beatriz, Xiang, Shi-Hua, Pancera, Marie, Herschhorn, Alon, Wang, Liping, Zeng, Xing, Desormeaux, Anik, Kwong, Peter D., Sodroski, Joseph
Format: Artigo
Langue:Inglês
Publié: American Society for Microbiology 2012
Sujets:
Genetic Diversity and Evolution
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3416166/
https://ncbi.nlm.nih.gov/pubmed/22696649
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.01076-12
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