Live-Attenuated Lentivirus Immunization Modulates Innate Immunity and Inflammation while Protecting Rhesus Macaques from Vaginal Simian Immunodeficiency Virus Challenge

Immunization with attenuated lentiviruses is the only reliable method of protecting rhesus macaques (RM) from vaginal challenge with pathogenic simian immunodeficiency virus (SIV). CD8(+) lymphocyte depletion prior to SIVmac239 vaginal challenge demonstrated that a modest, Gag-specific CD8(+) T cell...

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Autors principals: Genescà, Meritxell, Ma, Zhong-Min, Wang, Yichuan, Assaf, Basel, Qureshi, Huma, Fritts, Linda, Huang, Ying, McChesney, Michael B., Miller, Christopher J.
Format: Artigo
Idioma:Inglês
Publicat: American Society for Microbiology 2012
Matèries:
Pathogenesis and Immunity
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3416105/
https://ncbi.nlm.nih.gov/pubmed/22696662
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.00532-12
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