Live-Attenuated Lentivirus Immunization Modulates Innate Immunity and Inflammation while Protecting Rhesus Macaques from Vaginal Simian Immunodeficiency Virus Challenge

Immunization with attenuated lentiviruses is the only reliable method of protecting rhesus macaques (RM) from vaginal challenge with pathogenic simian immunodeficiency virus (SIV). CD8(+) lymphocyte depletion prior to SIVmac239 vaginal challenge demonstrated that a modest, Gag-specific CD8(+) T cell...

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Bibliografiset tiedot
Päätekijät: Genescà, Meritxell, Ma, Zhong-Min, Wang, Yichuan, Assaf, Basel, Qureshi, Huma, Fritts, Linda, Huang, Ying, McChesney, Michael B., Miller, Christopher J.
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: American Society for Microbiology 2012
Aiheet:
Pathogenesis and Immunity
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC3416105/
https://ncbi.nlm.nih.gov/pubmed/22696662
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.00532-12
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