Lysosomal Membrane Permeabilization is an Early Event in Sigma-2 Receptor Ligand Mediated Cell Death in Pancreatic Cancer

BACKGROUND: Sigma-2 receptor ligands have been studied for treatment of pancreatic cancer because they are preferentially internalized by proliferating cells and induce apoptosis. This mechanism of apoptosis is poorly understood, with varying reports of caspase-3 dependence. We evaluated multiple si...

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Hlavní autoři: Hornick, John R, Vangveravong, Suwanna, Spitzer, Dirk, Abate, Carmen, Berardi, Francesco, Goedegebuure, Peter, Mach, Robert H, Hawkins, William G
Médium: Artigo
Jazyk:Inglês
Vydáno: BioMed Central 2012
Témata:
Research
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3414770/
https://ncbi.nlm.nih.gov/pubmed/22551149
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1756-9966-31-41
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