Lysosomal Membrane Permeabilization is an Early Event in Sigma-2 Receptor Ligand Mediated Cell Death in Pancreatic Cancer

BACKGROUND: Sigma-2 receptor ligands have been studied for treatment of pancreatic cancer because they are preferentially internalized by proliferating cells and induce apoptosis. This mechanism of apoptosis is poorly understood, with varying reports of caspase-3 dependence. We evaluated multiple si...

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Enregistré dans:
Détails bibliographiques
Auteurs principaux: Hornick, John R, Vangveravong, Suwanna, Spitzer, Dirk, Abate, Carmen, Berardi, Francesco, Goedegebuure, Peter, Mach, Robert H, Hawkins, William G
Format: Artigo
Langue:Inglês
Publié: BioMed Central 2012
Sujets:
Research
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3414770/
https://ncbi.nlm.nih.gov/pubmed/22551149
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1756-9966-31-41
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