Molecular pharmacological profile of a novel thiazolinone-based direct and selective 5-lipoxygenase inhibitor

BACKGROUND AND PURPOSE: The potency of many 5-lipoxygenase (5-LOX) inhibitors depends on the cellular peroxide tone and the mechanism of 5-LOX enzyme activation. Therefore, new inhibitors that act regardless of the mode of enzyme activation need to be developed. Recently, we identified a novel class...

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Autors principals: Hofmann, B, Rödl, CB, Kahnt, AS, Maier, TJ, Michel, AA, Hoffmann, M, Rau, O, Awwad, K, Pellowska, M, Wurglics, M, Wacker, M, Živković, A, Fleming, I, Schubert-Zsilavecz, M, Stark, H, Schneider, G, Steinhilber, D
Format: Artigo
Idioma:Inglês
Publicat: Blackwell Publishing Ltd 2012
Matèries:
Research Papers
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3413864/
https://ncbi.nlm.nih.gov/pubmed/21955369
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1476-5381.2011.01707.x
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