Electrophilic Fatty Acid Species Inhibit 5-Lipoxygenase and Attenuate Sepsis-Induced Pulmonary Inflammation

Aims: The reaction of nitric oxide and nitrite-derived species with polyunsaturated fatty acids yields electrophilic fatty acid nitroalkene derivatives (NO(2)-FA), which display anti-inflammatory properties. Given that the 5-lipoxygenase (5-LO, ALOX5) possesses critical nucleophilic amino acids, whi...

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Detalhes bibliográficos
Main Authors: Awwad, Khader, Steinbrink, Svenja D., Frömel, Timo, Lill, Nicole, Isaak, Johann, Häfner, Ann-Kathrin, Roos, Jessica, Hofmann, Bettina, Heide, Heinrich, Geisslinger, Gerd, Steinhilber, Dieter, Freeman, Bruce A., Maier, Thorsten J., Fleming, Ingrid
Formato: Artigo
Idioma:Inglês
Publicado em: Mary Ann Liebert, Inc. 2014
Assuntos:
Original Research Communications
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4026401/
https://ncbi.nlm.nih.gov/pubmed/24206143
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1089/ars.2013.5473
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