A pirinixic acid derivative (LP105) inhibits murine 5-lipoxygenase activity and attenuates vascular remodelling in a murine model of aortic aneurysm

BACKGROUND AND PURPOSE: Arachidonic acid derivatives play a central role in inflammation processes. Arachidonic acid is metabolized by several enzymes, particularly cyclooxygenases (COX), 5-lipoxygenase (5-LOX) and microsomal prostaglandin E-synthase-1 (mPGES-1) to pro-inflammatory mediators. EXPERI...

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Detalhes bibliográficos
Main Authors: Revermann, M, Mieth, A, Popescu, L, Paulke, A, Wurglics, M, Pellowska, M, Fischer, AS, Steri, R, Maier, TJ, Schermuly, RT, Geisslinger, G, Schubert-Zsilavecz, M, Brandes, RP, Steinhilber, D
Formato: Artigo
Idioma:Inglês
Publicado em: Blackwell Publishing Ltd 2011
Assuntos:
Research Papers
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3166698/
https://ncbi.nlm.nih.gov/pubmed/21410457
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1476-5381.2011.01321.x
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