Anti-obesity efficacy of LH-21, a cannabinoid CB(1) receptor antagonist with poor brain penetration, in diet-induced obese rats

BACKGROUND AND PURPOSE: Peripheral blockade of cannabinoid CB(1) receptors has been proposed as a safe and effective therapy against obesity, putatively devoid of the adverse psychiatric side effects of centrally acting CB(1) receptor antagonists. In this study we analysed the effects of LH-21, a pe...

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Detalhes bibliográficos
Main Authors: Alonso, Mónica, Serrano, Antonia, Vida, Margarita, Crespillo, Ana, Hernandez-Folgado, Laura, Jagerovic, Nadine, Goya, Pilar, Reyes-Cabello, Carmen, Perez-Valero, Vidal, Decara, Juan, Macías-González, Manuel, Bermúdez-Silva, Francisco Javier, Suárez, Juan, Rodríguez de Fonseca, Fernando, Pavón, Francisco Javier
Formato: Artigo
Idioma:Inglês
Publicado em: Blackwell Publishing Ltd 2012
Assuntos:
Research Papers
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3413862/
https://ncbi.nlm.nih.gov/pubmed/21951309
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1476-5381.2011.01698.x
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