Quantitative Model of Cell Cycle Arrest and Cellular Senescence in Primary Human Fibroblasts

Primary human fibroblasts in tissue culture undergo a limited number of cell divisions before entering a non-replicative “senescent” state. At early population doublings (PD), fibroblasts are proliferation-competent displaying exponential growth. During further cell passaging, an increasing number o...

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Main Authors: Schäuble, Sascha, Klement, Karolin, Marthandan, Shiva, Münch, Sandra, Heiland, Ines, Schuster, Stefan, Hemmerich, Peter, Diekmann, Stephan
Format: Artigo
Jezik:Inglês
Izdano: Public Library of Science 2012
Teme:
Research Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3413708/
https://ncbi.nlm.nih.gov/pubmed/22879912
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0042150
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