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Long-Term Quiescent Fibroblast Cells Transit into Senescence

Cellular senescence is described to be a consequence of telomere erosion during the replicative life span of primary human cells. Quiescence should therefore not contribute to cellular aging but rather extend lifespan. Here we tested this hypothesis and demonstrate that cultured long-term quiescent...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Marthandan, Shiva, Priebe, Steffen, Hemmerich, Peter, Klement, Karolin, Diekmann, Stephan
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2014
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4274099/
https://ncbi.nlm.nih.gov/pubmed/25531649
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0115597
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