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Long-Term Quiescent Fibroblast Cells Transit into Senescence

Cellular senescence is described to be a consequence of telomere erosion during the replicative life span of primary human cells. Quiescence should therefore not contribute to cellular aging but rather extend lifespan. Here we tested this hypothesis and demonstrate that cultured long-term quiescent...

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發表在:PLoS One
Main Authors: Marthandan, Shiva, Priebe, Steffen, Hemmerich, Peter, Klement, Karolin, Diekmann, Stephan
格式: Artigo
語言:Inglês
出版: Public Library of Science 2014
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC4274099/
https://ncbi.nlm.nih.gov/pubmed/25531649
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0115597
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