Kinase-dead ATM protein causes genomic instability and early embryonic lethality in mice

Ataxia telangiectasia (A-T) mutated (ATM) kinase orchestrates deoxyribonucleic acid (DNA) damage responses by phosphorylating numerous substrates implicated in DNA repair and cell cycle checkpoint activation. A-T patients and mouse models that express no ATM protein undergo normal embryonic developm...

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Bibliographische Detailangaben
Hauptverfasser: Yamamoto, Kenta, Wang, Yunyue, Jiang, Wenxia, Liu, Xiangyu, Dubois, Richard L., Lin, Chyuan-Sheng, Ludwig, Thomas, Bakkenist, Christopher J., Zha, Shan
Format: Artigo
Sprache:Inglês
Veröffentlicht: The Rockefeller University Press 2012
Schlagworte:
Research Articles
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3413350/
https://ncbi.nlm.nih.gov/pubmed/22869596
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.201204098
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