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Inhibition of ATM kinase activity does not phenocopy ATM protein disruption: Implications for the clinical utility of ATM kinase inhibitors
Biallelic mutations in ataxiatelangiectasia mutated (ATM), which encodes for a protein kinase, cause ataxia telangiectasia (A–T). A–T is a pleiotropic disease, with a characteristic hypersensitivity to ionizing radiation (IR). A–T patients typically lack both detectable ATM protein and ATM kinase ac...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Landes Bioscience
2010
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3230471/ https://ncbi.nlm.nih.gov/pubmed/20953138 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/cc.9.20.13471 |
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