Ribosomal biogenesis genes play an essential and p53-independent role in zebrafish pancreas development

Mutations in the human Shwachman-Bodian-Diamond syndrome (SBDS) gene cause defective ribosome assembly and are associated with exocrine pancreatic insufficiency, chronic neutropenia and skeletal defects. However, the mechanism underlying these phenotypes remains unclear. Here we show that knockdown...

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Enregistré dans:
Détails bibliographiques
Auteurs principaux: Provost, Elayne, Wehner, Karen A., Zhong, Xiangang, Ashar, Foram, Nguyen, Elizabeth, Green, Rachel, Parsons, Michael J., Leach, Steven D.
Format: Artigo
Langue:Inglês
Publié: Company of Biologists 2012
Sujets:
Research Articles
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3413166/
https://ncbi.nlm.nih.gov/pubmed/22872088
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/dev.077107
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