Ribosomal biogenesis genes play an essential and p53-independent role in zebrafish pancreas development

Mutations in the human Shwachman-Bodian-Diamond syndrome (SBDS) gene cause defective ribosome assembly and are associated with exocrine pancreatic insufficiency, chronic neutropenia and skeletal defects. However, the mechanism underlying these phenotypes remains unclear. Here we show that knockdown...

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Bibliographic Details
Main Authors: Provost, Elayne, Wehner, Karen A., Zhong, Xiangang, Ashar, Foram, Nguyen, Elizabeth, Green, Rachel, Parsons, Michael J., Leach, Steven D.
Format: Artigo
Language:Inglês
Published: Company of Biologists 2012
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Research Articles
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3413166/
https://ncbi.nlm.nih.gov/pubmed/22872088
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/dev.077107
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