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Site-specific targeting of antibody activity in vivo mediated by disease-associated proteases
As a general strategy to selectively target antibody activity in vivo, a molecular architecture was designed to render binding activity dependent upon proteases in disease tissues. A protease-activated antibody (pro-antibody) targeting vascular cell adhesion molecule 1 (VCAM-1), a marker of atherosc...
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| Main Authors: | , , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2012
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3412904/ https://ncbi.nlm.nih.gov/pubmed/22634092 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jconrel.2012.05.035 |
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