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Quantitative specificity-based display library screening identifies determinants of antibody-epitope binding specificity

Despite the critical importance of molecular specificity in bimolecular systems, in vitro display technologies have been applied extensively for affinity maturation of peptides and antibodies without explicitly measuring the specificity of the desired interaction. We devised a general strategy to me...

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Detalhes bibliográficos
Main Authors: Hall, Sejal S, Daugherty, Patrick S
Formato: Artigo
Idioma:Inglês
Publicado em: Wiley Subscription Services, Inc., A Wiley Company 2009
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2777367/
https://ncbi.nlm.nih.gov/pubmed/19610073
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/pro.203
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