PEA-15 unphosphorylated at both serine 104 and serine 116 inhibits ovarian cancer cell tumorigenicity and progression through blocking β-catenin

Ovarian cancer is a major cause of death among women; there remains an urgent need to develop new effective therapies to target this cancer. Phosphoprotein enriched in astrocytes (PEA-15) is a 15-kDa phosphoprotein that is known to bind ERK1/2, thus blocking cell proliferation. The physiological act...

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Detalhes bibliográficos
Main Authors: Lee, J, Bartholomeusz, C, Krishnamurthy, S, Liu, P, Saso, H, LaFortune, T A, Hortobagyi, G N, Ueno, N T
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2012
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Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3412650/
https://ncbi.nlm.nih.gov/pubmed/23552738
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/oncsis.2012.22
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