Silencing Kinase Interacting Stathmin Gene Enhances Erlotinib Sensitivity by Inhibiting Serine 10 p27 Phosphorylation in EGFR-expressing Breast Cancer

The epidermal growth factor receptor (EGFR) signaling pathway has emerged as a promising target for cancer therapy. EGFR tyrosine kinase inhibitors (TKIs) such as erlotinib have been approved for cancer treatment but have demonstrated very limited activity in breast cancer patients. Clarifying the m...

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Bibliografiske detaljer
Main Authors: Zhang, Dongwei, Tari, Ana M., Akar, Ugur, Arun, Banu K., LaFortune, Tiffany A., Nieves-Alicea, Rene, Hortobagyi, Gabriel N., Ueno, Naoto T.
Format: Artigo
Sprog:Inglês
Udgivet: 2010
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3062953/
https://ncbi.nlm.nih.gov/pubmed/21045138
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1535-7163.MCT-10-0362
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