Interferon-β Sensitivity of Tumor Cells Correlates With Poor Response to VA7 Virotherapy in Mouse Glioma Models

In our recent study, replicative alphaviral vector VA7 was found to be effective against orthotopic human U87-glioma xenografts in an athymic mouse model eradicating the tumors with single intravenous (i.v.) injection. Here, we tested the efficacy of VA7 in immunocompetent orthotopic GL261 and CT-2A...

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Autors principals: Ruotsalainen, Janne, Martikainen, Miika, Niittykoski, Minna, Huhtala, Tuulia, Aaltonen, Tytti, Heikkilä, Jari, Bell, John, Vähä-Koskela, Markus, Hinkkanen, Ari
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group 2012
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Original Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3412495/
https://ncbi.nlm.nih.gov/pubmed/22434140
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mt.2012.53
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