Intravenously Administered Alphavirus Vector VA7 Eradicates Orthotopic Human Glioma Xenografts in Nude Mice

BACKGROUND: VA7 is a neurotropic alphavirus vector based on an attenuated strain of Semliki Forest virus. We have previously shown that VA7 exhibits oncolytic activity against human melanoma xenografts in immunodeficient mice. The purpose of this study was to determine if intravenously administered...

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Detalhes bibliográficos
Main Authors: Heikkilä, Jari E., Vähä-Koskela, Markus J. V., Ruotsalainen, Janne J., Martikainen, Miika W., Stanford, Marianne M., McCart, J. Andrea, Bell, John C., Hinkkanen, Ari E.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2010
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2799335/
https://ncbi.nlm.nih.gov/pubmed/20066051
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0008603
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