Directional DNA Methylation Changes and Complex Intermediate States Accompany Lineage Specificity in the Adult Hematopoietic Compartment

DNA methylation has been implicated as an epigenetic component of mechanisms that stabilize cell-fate decisions. Here, we have characterized the methylomes of human female hematopoietic stem/progenitor cells (HSPCs) and mature cells from the myeloid and lymphoid lineages. Hypomethylated regions (HMR...

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Hauptverfasser: Hodges, Emily, Molaro, Antoine, Dos Santos, Camila O., Thekkat, Pramod, Song, Qiang, Uren, Philip J., Park, Jin, Butler, Jason, Rafii, Shahin, McCombie, W. Richard, Smith, Andrew D., Hannon, Gregory J.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2011
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3412369/
https://ncbi.nlm.nih.gov/pubmed/21924933
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2011.08.026
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