Ubiquitin-Induced Oligomerization of the RNA Sensors RIG-I and MDA5 Activates Antiviral Innate Immune Response

RIG-I and MDA5 detect viral RNA in the cytoplasm and activate signaling cascades leading to the production of type-I interferons. RIG-I is activated through sequential binding of viral RNA and unanchored lysine-63 (K63) polyubiquitin chains, but how polyubiquitin activates RIG-I and whether MDA5 is...

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Bibliografiske detaljer
Main Authors: Jiang, Xiaomo, Kinch, Lisa, Brautigam, Chad A., Chen, Xiang, Du, Fenghe, Grishin, Nick, Chen, Zhijian J.
Format: Artigo
Sprog:Inglês
Udgivet: 2012
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3412146/
https://ncbi.nlm.nih.gov/pubmed/22705106
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.immuni.2012.03.022
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