Ubiquitin-Induced Oligomerization of the RNA Sensors RIG-I and MDA5 Activates Antiviral Innate Immune Response

RIG-I and MDA5 detect viral RNA in the cytoplasm and activate signaling cascades leading to the production of type-I interferons. RIG-I is activated through sequential binding of viral RNA and unanchored lysine-63 (K63) polyubiquitin chains, but how polyubiquitin activates RIG-I and whether MDA5 is...

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Bibliographic Details
Main Authors:	Jiang, Xiaomo, Kinch, Lisa, Brautigam, Chad A., Chen, Xiang, Du, Fenghe, Grishin, Nick, Chen, Zhijian J.
Format:	Artigo
Language:	Inglês
Published:	2012
Subjects:	Article
Online Access:	https://ncbi.nlm.nih.gov/pmc/articles/PMC3412146/ https://ncbi.nlm.nih.gov/pubmed/22705106 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.immuni.2012.03.022
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Ubiquitin-Induced Oligomerization of the RNA Sensors RIG-I and MDA5 Activates Antiviral Innate Immune Response

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