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TRIM65-catalized ubiquitination is essential for MDA5-mediated antiviral innate immunity
MDA5 plays a critical role in antiviral innate immunity by functioning as a cytoplasmic double-stranded RNA sensor that can activate type I interferon signaling pathways, but the mechanism for the activation of MDA5 is poorly understood. Here, we show that TRIM65 specifically interacts with MDA5 and...
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| Publicado no: | J Exp Med |
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| Main Authors: | , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
The Rockefeller University Press
2017
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5294850/ https://ncbi.nlm.nih.gov/pubmed/28031478 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20160592 |
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