TRIM65-catalized ubiquitination is essential for MDA5-mediated antiviral innate immunity

MDA5 plays a critical role in antiviral innate immunity by functioning as a cytoplasmic double-stranded RNA sensor that can activate type I interferon signaling pathways, but the mechanism for the activation of MDA5 is poorly understood. Here, we show that TRIM65 specifically interacts with MDA5 and...

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Detaylı Bibliyografya
Yayımlandı:J Exp Med
Asıl Yazarlar: Lang, Xueting, Tang, Tiantian, Jin, Tengchuan, Ding, Chen, Zhou, Rongbin, Jiang, Wei
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: The Rockefeller University Press 2017
Konular:
Research Articles
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC5294850/
https://ncbi.nlm.nih.gov/pubmed/28031478
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20160592
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