SIRT7 links H3K18 deacetylation to maintenance of oncogenic transformation

Sirtuin proteins regulate diverse cellular pathways that influence genomic stability, metabolism, and ageing(1,2). SIRT7 is a mammalian sirtuin whose biochemical activity, molecular targets, and physiologic functions have been unclear. Here we show that SIRT7 is an NAD(+)-dependent H3K18Ac (acetylat...

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Detalhes bibliográficos
Main Authors: Barber, Matthew F., Michishita-Kioi, Eriko, Xi, Yuanxin, Tasselli, Luisa, Kioi, Mitomu, Moqtaderi, Zarmik, Tennen, Ruth I., Paredes, Silvana, Young, Nicolas L., Chen, Kaifu, Struhl, Kevin, Garcia, Benjamin A., Gozani, Or, Li, Wei, Chua, Katrin F.
Formato: Artigo
Idioma:Inglês
Publicado em: 2012
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3412143/
https://ncbi.nlm.nih.gov/pubmed/22722849
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature11043
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