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Chromatin regulation and genome maintenance by mammalian SIRT6
Saccharomyces cerevisiae Sir2 is an NAD(+)-dependent histone deacetylase that links chromatin silencing to genomic stability, cellular metabolism, and lifespan regulation. In mice, deficiency for the Sir2 family member SIRT6 leads to genomic instability, metabolic defects, and degenerative pathologi...
Gorde:
| Egile Nagusiak: | , |
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| Formatua: | Artigo |
| Hizkuntza: | Inglês |
| Argitaratua: |
2010
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| Gaiak: | |
| Sarrera elektronikoa: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2991557/ https://ncbi.nlm.nih.gov/pubmed/20729089 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.tibs.2010.07.009 |
| Etiketak: |
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