Severe hyperhomocysteinemia promotes bone marrow-derived and resident inflammatory monocyte differentiation and atherosclerosis in LDLr/CBS-deficient mice

BACKGROUND: This study examined the causative role of hyperhomocysteinemia (HHcy) in atherogenesis and its effect on inflammatory monocyte (MC) differentiation. METHODS AND RESULTS: We generated a novel HHcy and hyperlipidemia mouse model, in which cystathionine β-synthase (CBS) and low-density lipo...

Full beskrivning

Sparad:
Bibliografiska uppgifter
Huvudupphovsmän: Zhang, Daqing, Fang, Pu, Jiang, Xiaohua, Nelson, Jun, Moore, Jodene K, Kruger, Warren D, Berretta, Remus M, Houser, Steven R, Yang, Xiaofeng, Wang, Hong
Materialtyp: Artigo
Språk:Inglês
Publicerad: 2012
Ämnen:
Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC3412115/
https://ncbi.nlm.nih.gov/pubmed/22628578
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/CIRCRESAHA.112.269472
Taggar: Lägg till en tagg
Inga taggar, Lägg till första taggen!

Liknande verk