Severe hyperhomocysteinemia promotes bone marrow-derived and resident inflammatory monocyte differentiation and atherosclerosis in LDLr/CBS-deficient mice

BACKGROUND: This study examined the causative role of hyperhomocysteinemia (HHcy) in atherogenesis and its effect on inflammatory monocyte (MC) differentiation. METHODS AND RESULTS: We generated a novel HHcy and hyperlipidemia mouse model, in which cystathionine β-synthase (CBS) and low-density lipo...

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Detalhes bibliográficos
Main Authors: Zhang, Daqing, Fang, Pu, Jiang, Xiaohua, Nelson, Jun, Moore, Jodene K, Kruger, Warren D, Berretta, Remus M, Houser, Steven R, Yang, Xiaofeng, Wang, Hong
Formato: Artigo
Idioma:Inglês
Publicado em: 2012
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3412115/
https://ncbi.nlm.nih.gov/pubmed/22628578
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/CIRCRESAHA.112.269472
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