miR-29ab1-deficiency Identifies a Negative Feedback Loop Controlling Th1 Bias that is Dysregulated in Multiple Sclerosis()

T-helper cell programming and function is tightly regulated by complex biological networks to prevent excessive inflammatory responses and autoimmune disease. The importance of miRNAs in this process is highlighted by the preferential Th1 polarization of Dicer-deficient T cells that lack miRNAs. Usi...

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Autores principales: Smith, Kristen M., Guerau-de-Arellano, Mireia, Costinean, Stefan, Williams, Jessica L., Bottoni, Arianna, Cox, Gina Mavrikis, Satoskar, Abhay R., Croce, Carlo M., Racke, Michael K., Lovett-Racke, Amy E., Whitacre, Caroline C.
Formato: Artigo
Lenguaje:Inglês
Publicado: 2012
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3411895/
https://ncbi.nlm.nih.gov/pubmed/22772450
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1103171
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