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Increased miR-29b in the aged brain correlates with the reduction of IGF-1 and CX(3)CL1

Microglia develop an inflammatory phenotype during normal aging. The mechanism by which this occurs is not well understood, but may be related to impairments in several key immunoregulatory systems. Here we show that miR-29a and miR-29b, two immunoregulatory micro-RNAs, were increased in the brain o...

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Detalhes bibliográficos
Main Authors: Fenn, Ashley M, Smith, Kristen M, Lovett-Racke, Amy E, Guerau-de-Arellano, Mireia, Whitacre, Caroline C, Godbout, Jonathan P
Formato: Artigo
Idioma:Inglês
Publicado em: 2013
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3779520/
https://ncbi.nlm.nih.gov/pubmed/23880139
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neurobiolaging.2013.06.007
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