TGF-β signaling via smad4 drives IL-10 production in effector Th1 cells and reduces T cell trafficking in EAE

Effector Th1 cells perpetuate inflammatory damage in a number of autoimmune diseases, including MS and its animal model EAE. Recently, a self-regulatory mechanism was described where effector Th1 cells produce the immunomodulatory cytokine IL-10 to dampen the inflammatory response in both normal and...

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Detalhes bibliográficos
Main Authors: Huss, David J., Winger, Ryan C., Cox, Gina Mavrikis, Guerau-de-Arellano, Mireia, Yang, Yuhong, Racke, Michael K., Lovett-Racke, Amy E.
Formato: Artigo
Idioma:Inglês
Publicado em: 2011
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3478765/
https://ncbi.nlm.nih.gov/pubmed/21728174
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/eji.201141666
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