Dimethyl Fumarate Inhibits Dendritic Cell Maturation via Nuclear Factor κB (NF-κB) and Extracellular Signal-regulated Kinase 1 and 2 (ERK1/2) and Mitogen Stress-activated Kinase 1 (MSK1) Signaling

Dimethyl fumarate (DMF) is an effective novel treatment for multiple sclerosis in clinical trials. A reduction of IFN-γ-producing CD4(+) T cells is observed in DMF-treated patients and may contribute to its clinical efficacy. However, the cellular and molecular mechanisms behind this clinical observ...

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Detalhes bibliográficos
Main Authors: Peng, Haiyan, Guerau-de-Arellano, Mireia, Mehta, Veela B., Yang, Yuhong, Huss, David J., Papenfuss, Tracey L., Lovett-Racke, Amy E., Racke, Michael K.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2012
Assuntos:
Immunology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3431702/
https://ncbi.nlm.nih.gov/pubmed/22733812
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.383380
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