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TGFβ-Stimulated MicroRNA-21 Utilizes PTEN to Orchestrate AKT/mTORC1 Signaling for Mesangial Cell Hypertrophy and Matrix Expansion

Transforming growth factor-β (TGFβ) promotes glomerular hypertrophy and matrix expansion, leading to glomerulosclerosis. MicroRNAs are well suited to promote fibrosis because they can repress gene expression, which negatively regulate the fibrotic process. Recent cellular and animal studies have rev...

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Библиографические подробности
Главные авторы: Dey, Nirmalya, Ghosh-Choudhury, Nandini, Kasinath, Balakuntalam S., Choudhury, Goutam Ghosh
Формат: Artigo
Язык:Inglês
Опубликовано: Public Library of Science 2012
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Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC3411779/
https://ncbi.nlm.nih.gov/pubmed/22879939
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0042316
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