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Two Deafness-causing (DFNA20/26) Actin Mutations Affect Arp2/3-dependent Actin Regulation

Hearing requires proper function of the auditory hair cell, which is critically dependent upon its actin-based cytoskeletal structure. Currently, ten point mutations in nonmuscle γ-actin have been identified as causing progressive autosomal dominant nonsyndromic hearing loss (DFNA20/26), highlightin...

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Detalhes bibliográficos
Main Authors: Kruth, Karina A., Rubenstein, Peter A.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2012
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3411063/
https://ncbi.nlm.nih.gov/pubmed/22718764
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.377283
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