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Two Deafness-Causing Actin Mutations (DFNA20/26) Have Allosteric Effects on the Actin Structure

Point mutations in γ-cytoplasmic actin have been shown to result in autosomal-dominant, nonsyndromic, early-onset deafness. Two mutations at the same site, K118M and K118N, provide a unique opportunity to compare the effects of two dissimilar amino acid substitutions that produce a similar phenotype...

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Detalhes bibliográficos
Publicado no:Biophys J
Main Authors: Jepsen, Lauren, Kruth, Karina A., Rubenstein, Peter A., Sept, David
Formato: Artigo
Idioma:Inglês
Publicado em: The Biophysical Society 2016
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4968419/
https://ncbi.nlm.nih.gov/pubmed/27463135
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bpj.2016.06.012
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