Rearranging Exosites in Noncatalytic Domains Can Redirect the Substrate Specificity of ADAMTS Proteases

ADAMTS proteases typically employ some combination of ancillary C-terminal disintegrin-like, thrombospondin-1, cysteine-rich, and spacer domains to bind substrates and facilitate proteolysis by an N-terminal metalloprotease domain. We constructed chimeric proteases and substrates to examine the role...

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Detalles Bibliográficos
Main Authors: Gao, Weiqiang, Zhu, Jian, Westfield, Lisa A., Tuley, Elodee A., Anderson, Patricia J., Sadler, J. Evan
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Biochemistry and Molecular Biology 2012
Assuntos:
Enzymology
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3411030/
https://ncbi.nlm.nih.gov/pubmed/22707719
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.380535
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