Lethal, Hereditary Mutants of Phospholamban Elude Phosphorylation by Protein Kinase A

The sarcoplasmic reticulum calcium pump (SERCA) and its regulator, phospholamban, are essential components of cardiac contractility. Phospholamban modulates contractility by inhibiting SERCA, and this process is dynamically regulated by β-adrenergic stimulation and phosphorylation of phospholamban....

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Bibliographische Detailangaben
Hauptverfasser: Ceholski, Delaine K., Trieber, Catharine A., Holmes, Charles F. B., Young, Howard S.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Biochemistry and Molecular Biology 2012
Schlagworte:
Molecular Bases of Disease
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3411000/
https://ncbi.nlm.nih.gov/pubmed/22707725
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.382713
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