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Lethal, Hereditary Mutants of Phospholamban Elude Phosphorylation by Protein Kinase A
The sarcoplasmic reticulum calcium pump (SERCA) and its regulator, phospholamban, are essential components of cardiac contractility. Phospholamban modulates contractility by inhibiting SERCA, and this process is dynamically regulated by β-adrenergic stimulation and phosphorylation of phospholamban....
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| Autori principali: | , , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
American Society for Biochemistry and Molecular Biology
2012
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3411000/ https://ncbi.nlm.nih.gov/pubmed/22707725 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.382713 |
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