Transcription Factors Sp1 and p73 Control the Expression of the Proapoptotic Protein NOXA in the Response of Testicular Embryonal Carcinoma Cells to Cisplatin

Testicular germ cell tumors (TGCTs) are highly responsive to and curable by cisplatin-based chemotherapy even in advanced stages. We have studied the molecular mechanisms involved in the induction of apoptosis in response to cisplatin, and found that proapoptotic Noxa is transcriptionally up-regulat...

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Detalhes bibliográficos
Main Authors: Grande, Lara, Bretones, Gabriel, Rosa-Garrido, Manuel, Garrido-Martin, Eva M., Hernandez, Teresa, Fraile, Susana, Botella, Luisa, de Alava, Enrique, Vidal, August, Garcia del Muro, Xavier, Villanueva, Alberto, Delgado, M. Dolores, Fernandez-Luna, Jose L.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2012
Assuntos:
Gene Regulation
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3410991/
https://ncbi.nlm.nih.gov/pubmed/22718761
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.376319
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