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Numb regulates stability and localization of the mitotic kinase PLK1 and is required for transit through mitosis
Numb functions in progenitor cell fate determination and early development but it is also expressed in post-developmental tissues and cancers where its role is unclear. In this study, we report that a targeted knockdown of Numb expression causes a G2/M arrest and reduced cell growth in human melanom...
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| Main Authors: | , , , , , |
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| Format: | Artigo |
| Language: | Inglês |
| Published: |
2012
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| Subjects: | |
| Online Access: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3410979/ https://ncbi.nlm.nih.gov/pubmed/22593191 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-12-0714 |
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