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Targeted depletion of Polo-like kinase (Plk) 1 via lentiviral shRNA or a small-molecule inhibitor causes mitotic catastrophe and induction of apoptosis in human melanoma cells
Melanoma, one of the most lethal forms of skin cancer, remains resistant to currently available treatments. Therefore, novel mechanism and target-based approaches are needed for the management of this neoplasm. Polo-like kinase 1 (Plk1) has been shown to be a crucial regulator of mitotic entry, prog...
Gorde:
| Egile Nagusiak: | , , , , |
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| Formatua: | Artigo |
| Hizkuntza: | Inglês |
| Argitaratua: |
2009
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| Gaiak: | |
| Sarrera elektronikoa: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2799787/ https://ncbi.nlm.nih.gov/pubmed/19554017 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/jid.2009.172 |
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