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Tankyrase 1 regulates centrosome function by controlling CPAP stability
CPAP—a gene mutated in primary microcephaly—is required for procentriole formation. Here we show that CPAP degradation and function is controlled by the poly(ADP-ribose) polymerase tankyrase 1. CPAP is PARsylated by tankyrase 1 in vitro and in vivo. Overexpression of tankyrase 1 leads to CPAP protea...
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| Hauptverfasser: | , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
Nature Publishing Group
2012
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3410387/ https://ncbi.nlm.nih.gov/pubmed/22699936 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/embor.2012.86 |
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